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Result of co-research with Tsukuba University
Study of functions 1st stage

Test for colorectal cancer cell growth suppression effect


Antitumor assay

Test using ES fermented soybeans


This assay uses MTT method to evaluate cancer Cell proliferation suppression


Cell used

Intestine cancer cell / Caco-2
Intestinal epithelial cell of human




Result


Suppression is concentration dependent as seen on the graph.



Mechanism



Colorectal cancer cell proliferation suppression was confirmed; mechanism of the action was evaluated


Evaluated with GUAVA-PCA
(DNA was stained to evaluate cell cycle)


Suppression is concentration dependent as seen on the graph.




Result


See the red undeline


Suppression in Cell cycle G2/M was discovered



(Reference) Features of Cell Cycle G2/M Period Suppression


Functionality Study 1st Stage Conclusion



The result of the recent study with researchers
at Tsukuba University was published in a journal of food science

Subject: "Suppression effect and its mechanism of colorectal cancer cell
proliferation by fermented soybean product"

· Han Junkyu
Tsukuba University Graduate School of Life and Envrironmental Sciences
Researcher


· Hiroko Isoda
Tsukuba University Graduate School of Life and Envrironmental Sciences
Assistant Professor


· Yukio Arai
Representative Director, Ecosunte Co., Ltd.
1992 Office Arai established
1999 Ecosunte Co, Ltd. incorporated
Appointed as the representative of the board to present